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COPD patients suffer from chronic inflammation of the respiratory tract. Certain enzymes, so-called protein kinases, regulate the inflammation process.
They are indirectly over-activated due to smoking, due to pro-inflammatory factors characteristic of COPD, and due to respiratory infections.
This results in the production of even more pro-inflammatory factors, which, in turns, promotes disease progression. According to the researchers, Narrow Spectrum Kinase Inhibitors, i.
NSKI, that inhibit protein kinases constitute a promising therapy approach. Two NSKIs — namely RV und RV, which were identified and provided by RespiVert for the studies — were tested by the team in cell cultures; the researchers compared their efficacy with a conventional corticosteroid and various Single Protein Kinase Inhibitors, which are likewise considered potential drug candidates.
The NSKIs were more effective in decelerating the production of inflammatory agents than any of the reference substances. A number of small molecule inhibitors of specific single kinases have previously been successfully tested in preclinical trials and advanced to clinical studies.
These substances selectively inhibit individual protein kinases or a family of protein kinases. Therefore, the team tested new drug candidates that target not only one protein kinase or a family of protein kinases, but a specific spectrum of several protein kinase families.
In the research lab at the Bergmannsheil Pneumology Clinic, researchers then tested the substances in primary cultures of airway smooth muscle cells taken from COPD patients.
Consequently, he and his colleagues believe that the findings gained in the preclinical model offer an immense potential for a transfer to applications in patient care.
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A vandalized exhibition honoring Jewish athletes in Bochum, Germany on November 11, Courtesy Bagrut e.
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